Skin aging is a multifactorial problem which involves free radical, cell cycle, and glycation mechanism. Hence, antioxidants become a prominent solution to this problem. Supplementation of Coenzyme Q10 as a promising antioxidant for skin aging has not been widely discussed. Thus, a systematic review was conducted following the 2020 Preferred Reporting Itemsfor Systematic Reviews and Meta-analyses (PRISMA) guideline and critically appraised. Ten studies focusing on efficacy and dose of CoQ10 for skin aging through oral and topical route were included in this systematic review. Studies were categorised into 3 animal study, 3 clinical stand-alone CoQ10 study, and 4 clinical CoQ10 combination study. In this review, it was confirmed that CoQ10 benefits the skin through reduction of wrinkle and fine lines, overall signs of photoaging, and inflammatory cytokines’ activity. Further study needs to be conducted on ideal oral and topical dose along with safety and tolerability of topical CoQ10.