Background: Despite extensive efforts by both the community and government, COVID-19 remains a persistent threat. Vaccination and adherence to COVID-appropriate behaviours are crucial in curbing the pandemic. This study aimed to assess awareness, acceptance, and determinants of COVID-19 vaccination. Materials and Methods: An analytical cross-sectional study involving 400 respondents after obtaining verbal consent,was conducted between February 5th and February 20th, 2022. Structured questionnaires collected data on socio-demographics, COVID-19 infection/vaccination status, vaccine awareness, motivation, and reasons for refusal. Results: Among 400 respondents, 62.7% were aged 18-40 years, and 67.8% were male. High awareness (96%) of vaccine protection against infection was observed, with 99.8% supporting compulsory vaccination. Most (94.7%) were vaccinated for self-protection, citing efficacy doubts and side effect concerns as primary reasons for refusal. Conclusion: The study highlights satisfactory awareness and positive attitudes toward COVID-19 vaccination. Enhanced awareness campaigns and addressing safety concerns can further boost vaccine acceptance. Accurate vaccine information is essential to promote adherence to government guidelines in combating vaccine-preventable diseases.