The present study aims to assess the estimating the life expectances to circulatory system disease (CSD) among the patients at various age intervals using life table models (LTMs). Age specific mortality data of CSD was used to estimate the life expectancy with various ages of both genders of Indians. The gender differentials in years of life lost by CSD patients are studied. The results indicated that the life expectancy for female is statistically significant when compared with males at all ages of CSD and also life lost more in female were observed.