Introduction: Psoriasis is a common, chronic, immune-mediated, multisystem, inflammatory disorder. It affects all age groups, including infants.  Psoriasis is associated with a variety of psychological problems. Aim: The aim of study is to assess Depression, Anxiety, QOL and Coping in patient of Psoriasis. Materials and Methods: APROSPECTIVE Hospital-Based study of clinically diagnosed Psoriasis cases studied over six months from September2023 to February 2024 comprising of 35 cases. PASI score was done on the day ofinitial assessment along with subjecting the patient to Hamilton Anxiety Rating Scale to assess quantum of anxiety, Hamilton Depression rating scale to quantum depression, QOL questionnaire and, brief cope. Results & Conclusion: Psoriasis affectsthe anxiety and depression outcomes as also the quality of life and coping. Even though there was no statistical correlation a clinical association was seen. The utility of the study is well in place and further understanding through research based upon bigger sample size is suggested.