Background: Surgical extraction of impacted mandibular third molars is a common procedure often accompanied by troublesome post-operative issues like swelling, pain, and limited mouth opening. The choice of wound closure method, be it primary closure or secondary healing, greatly affects these complications. Excessive discomfort can result from the inflammatory responses triggered by the surgical trauma, Methods: The study involved a total of 60 patients (26 females and 34 males), with each group (Group A and Group B) comprising 17 males and 13 females. Both groups had similar average ages. The surgery duration for both groups was also comparable. Post-operative parameters, including pain, swelling, and trismus, were assessed using the VAS40 score, AID and TID values, and evaluations by an investigator, Results: Following surgery, Group A reported notably higher pain scores after 6 hours, while Group B displayed higher scores after 12 hours and from the 2nd to the 7th post-operative day. Post-surgery, Group B also exhibited more swelling, with statistically significant differences observed on various post-operative days. The investigator's evaluations confirmed these findings, revealing more significant reductions in mouth opening for Group B from the second post-operative day onward, Conclusion: The present study supports the effectiveness of secondary intention wound closure in reducing post-operative swelling, pain, and trismus. This technique is budget-friendly and does not demand specialized skills or complex equipment. Further research with a larger participant pool is needed to validate its efficacy.