Published Paper


In-Silico Analysis of Bael Leaves Phyto-Components Treatment Against Corneal Opacity of Amur Carp (Cyprinusrubrofuscus)

Lopamudra Sahoo1, Yashaswi Nayak1*, Sagar Rout3
Odisha, India
Page: 928-942
Published on: 2024 June

Abstract

India has the oldest herbal practices in the world. Many studies have investigated the use of phytoconstituents found in plants in the treatment of various diseases. However, there are currently few studies on the phytoconstituent properties and pharmacological effects of Aegle marmelos. This study used computer simulation methods to try to discover the therapeutic potential of plant components in the leaves of Aegle marmelosin treating eye opacity in Northeastern carp. Auto Dock software was used to perform in silico analysis and Bio was used to visualize the docking results via Discovery Studio.This study focuses on screening the therapeutic activity of potential pharmacophores in the gene responsible for eye opacity in Cyprinus rubrofuscus(i.e., Amur carp). Computer analysis. Studies such as drug probability, pharmacokinetic properties, rule of five, and bioavailability radar play a crucial role in identifying suitable pharmacophore groups for further insillico.ico analysis. The molecular docking of seven selected compounds showed good interactions with the desired eye proteins and revealed significant binding affinities. Among the seven compounds, Cuminaldehyde (13.60 Kcal/mol) showed a higher molecular docking score, providing concrete evidence that the application of sweet-scented osmanthus plant components can be an effective strategy for treating eye opacity in carp.

 

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