One of Medicinal plant, Momordicacharantiabelonging to Cucurbitaceae family contains various essential phytocompounds which shows antifungal, antibacterial, antiviral, anti-neuronal properties. Alzheimer’s disease is a brain disorder that slowly destroys memory and thinking skills. And also reducing the ability to carry out the simplest tasks.In an insightful In-silico analysis and potential therapeutic efficacy of Momordicacharantia phytochemicals against amyloid beta (Aβ) protein, a key player in neurodegenerative disorders like Alzheimer's disease. In the present study, in silico molecular docking analysis of report phytocomponents present in M. charantia fruit was studied against Amyloid beta protein of Alzheimer’s disease.. The result revealed 38 phytochemicals constituents of Momordicacharantia derived from several literature of Review. Out of these 38 phytocompounds, Laurifolin , gamma Isomorphine, Armepavine, 3-Epi-Schelhammericine and Flabelline were ranked the highest with binding scores ranging from −10.0 kcal/mol to −9.4 kcal/mol compared with the standard, Cholamide, with a binding score of −7.7 kcal/mol. From the results obtained, it can be concluded that Laurifolin , gamma Isomorphine, Armepavine, 3-Epi-Schelhammericine and Flabelline act against  Alzheimer's disease  inhibiting the Amyloid Beta Protein and therefore can be further developed into potent drugs for Alzheimer's disease  treatment.