Introduction: One of the main causes of morbidity and mortality is depression. Over 350 million people worldwide, across all age groups, suffer from depression. It contributes significantly to the burden of diseases worldwide.  Aim: This study was designed to evaluate for anti-depressant activity of the indigenous medicinal plant Anisochilus petraeus. Result: A stronger inhibition comparable to the standard was observed with an APEM higher dose of 500 mg/kg of the test medication. The conventional model had the highest locomotion rate (85.6%), which was followed by 74% for APEM 400 mg/kg, 24.9 % for APEM, and 14.30% for /kg in the FST model. Greater locomotion was observed at the 400 mg/kg test drug dose, which was comparable to the control and standard. Conclusion: According to the study's findings, oral APDM can effectively provide observed antidepressant-like effects.