The current study aims to highlight specific voice parameters which could be seen more prominently in the cases of substance use relapse as compared to the non-relapse cases. The current study tries to present the possibilities of relapse in the cases of substance use based on voice samples. As literature suggests a strong correlation of neural markers in substance use, current study also considers EEG excerpt as a biomarker to postulate, strengthened and substantiate findings. The major aim of the study is to explore accuracy of Layered Voice Analysis (LVA) as an objective tool in predicting its clinical utility.