Abstract

Background:- The complex clinical, histological, and genetic features that differentiate these diseases are explored in this narrative review. The review summarizes recent research with an emphasis on the thorough investigation of these oral mucosal illnesses, Aim:- Investigating histological, clinical, and molecular markers in detail was the main goal, with a focus on differentiating between oral lichen planus (OLP) and oral lichenoid reaction (OLR). The objective was to present an in-depth understanding of the intricate components that go into the differential diagnosis, Methodology:- Inclusion criteria which covered material from 2000 to 2023 and focused on English-language studies including human patients with OLP and OLR. A thorough investigation was guaranteed by a methodical search approach using a variety of databases (such as Pubmed Central, Google scholar, Scopus, Web of Science, etc.) and manual searches. MeSH phrases and free-text keywords made it easier to explore the subtleties of histology, clinical, and molecular aspects, Results:- The results were categorized into molecular markers, histological features, and clinical presentations using thematic data synthesis. A clear and thorough analysis was provided by the qualitative transformation of the synthesized data, which revealed subtle distinctions between OLR and OLP.Conclusion:- For pathologists, doctors, and researchers negotiating the complex terrain of OLP and OLR, this article is an invaluable resource. It helps improve treatment plans and diagnostic precision for these intricate oral diseases by combining several elements.