Abstract: Vitex negundo (VN) and Aristolochiatangala (AT) are two medicinal plants deeply rooted in traditional medicine systems across various cultures. In recent years, scientific research has shed light on their phytochemical composition and pharmacological properties, uncovering their potential therapeutic benefits. This review aims to consolidate the current understanding of VN and AT by exploring their phytochemistry and pharmacology.V. negundo, commonly known as "Nirgundi" or "Five-leaved chaste tree," is renowned for its diverse pharmacological activities, including anti-inflammatory, analgesic, antimicrobial, antioxidant, and anticancer properties. The bioactive compounds identified in VN, such as flavonoids, alkaloids, terpenoids, and phenolic compounds, contribute to its broad spectrum of therapeutic effects.Aristolochiatangala, also known as "Tadari," is another medicinal plant with significant traditional use. Despite concerns regarding the safety of some Aristolochia species, recent studies have highlighted the pharmacological potential of A. tangala, particularly its antioxidant, anti-inflammatory, antidiabetic, antimicrobial, and hepatoprotective activities. The phytochemical analysis of A. tangala has revealed the presence of aristolochic acid derivatives, flavonoids, alkaloids, and terpenoids, among other bioactive constituents.This review comprehensively examines the phytochemical profiles of VN and AT and correlates them with their pharmacological effects. Furthermore, it discusses the mechanisms of action underlying their therapeutic properties, providing insights into their potential applications in the treatment and management of various ailments.Thus, Vitex negundo and Aristolochiatangala represent promising sources of natural remedies with diverse pharmacological activities. Further research focusing on elucidating their mechanisms of action, pharmacokinetics, and safety profiles is warranted to fully harness their therapeutic potential and facilitate their integration into modern healthcare practices.