Abstract

Background:Psoriasis is a chronic immune-mediated inflammatory skin disorder characterized by erythematous plaques with silver scales. Recent years have witnessed significant advancements in understanding its pathogenesis and developing novel therapeutic approaches. This review aims to provide a comprehensive overview of recent advancements in the diagnosis and management of psoriasis. Methods: A systematic literature search was conducted using electronic databases to identify relevant studies published in peer-reviewed journals. Articles focusing on diagnostic modalities, conventional treatments, biologic therapies, and emerging treatment strategies for psoriasis were included. The retrieved literature was critically analyzed to synthesize key findings and present a comprehensive overview of recent advancements in the field. Results: Accurate diagnosis is fundamental for effective management of psoriasis. Clinical presentation, histopathology, imaging techniques, and genetic testing serve as diagnostic modalities, aiding in confirming the diagnosis and assessing disease severity. Conventional treatments including topical therapies, phototherapy, and systemic medications remain essential components of psoriasis management, supplemented by the advent of biologic therapies targeting specific cytokines. Biologic agents such as TNF-alpha inhibitors, IL-17 inhibitors, and IL-23 inhibitors have demonstrated superior efficacy and safety profiles compared to conventional therapies. Emerging treatment strategies including small molecule inhibitors and immunomodulatory agents offer promising alternatives for patients resistant to or intolerant of biologic therapies.Conclusion: Recent advancements in the diagnosis and management of psoriasis have transformed patient care, offering a range of effective treatment options with improved safety profiles and outcomes. Accurate diagnosis facilitated by clinical assessment and ancillary diagnostic modalities guides personalized treatment approaches tailored to individual patient needs. Conventional treatments, biologic therapies, and emerging treatment strategies complement each other, providing comprehensive management options for patients with psoriasis. However, challenges including long-term safety concerns, treatment access disparities, and the need for personalized treatment approaches persist, emphasizing the importance of ongoing research and collaborative efforts to optimize patient care and address existing challenges in psoriasis management.