Abstract

One of the characteristics that self- nanoemulsifying drug delivery systems (SNEDDS) are categorized based on is the size of the droplets that are produced after dispersion. One characteristic of Self-Micro Emulsifying Drug Delivery Systems (SMEDDS) is a droplet. Self-Nano Emulsifying Drug Delivery Systems have droplet sizes of less than 100 nm, although their dispersion sizes range from 100 to 250 nm. Isotropic mixtures of natural or synthetic oils, surfactants, and cosurfactants, known as SNEDDS, have the rare ability to produce fine oil in water (O/W) nano-emulsions with a diameter of less than 100 nm when diluted with water and gently swirled. An SNEDDS formulation can be optimized by phase diagram techniques or statistical design of experiments. SNEDDS improves the oral bioavailability of hydrophobic drugs in a variety of ways. The final formulation's average globule size, dispersibility study, and Polydispersibility Index (PDI) were all examined. The globule size of the optimized system will be less than 100 nm, perhaps falling below the range of tolerable nanoemulsions.