Problem: Limited evidences are available in Ethiopian context concerning prosocial behavior and its contributing factors as compared to antisocial behavior among in school adolescents. Most studies have focused on antisocial behavior than prosocial behavior. Thus, the main purpose of this study was to examine the contributions of parenting dimensions, religiosity, peer influence and self-esteem to adolescents’ prosocial behavior. Approach: A cross sectional survey design was used. Self-report questionnaires were utilized to collect data from selected 225 students using simple random sampling. Findings: acceptance/involving of both father and mother parenting dimensions positive and significantly related to prosocial behavior (r = .17 & r=.19) respectively. Religiosity and self-esteem of the participants were also positively and significantly related to prosocial (r = .23 & r = .13) correspondingly. Multiple regression analysis results also showed despite the small effect sizes revealed, fathers’ acceptance dimension and religiosity, and mothers’ acceptance dimension and religiosity of the participants significantly predicted prosocial behavior among other variables and explained 10.4% and 8.6 % of the variance of participants’ prosocial behaviors respectively. A one-way ANOVA revealed no significant effect of the four parenting style of fathers and mothers on prosocial behavior, F (3,221) = 1.95; F (3,221) = 1.83 p > 0.05 respectively. In conclusion, the acceptance parenting dimension of both fathers and mothers and religiosity of the adolescents were the major contributors of prosocial behavior tendencies. The entire findings shown that despite positive contributions were observed, the effect sizes were small. This implies, much will be expected from parents, religious institutions and other concerned bodies topromote prosocial behaviors of the adolescents.