Although Organic Rankine cycles does not require the combustion of its working fluid, the choice of operating refrigerants pose significant environmental impact from construction, operation and decommissioning phases. This research work focused on the evaluation of possible environmental impacts of an adapted power-cooling organic Rankine cycle using six different refrigerants with respect to the power generation potential within the system’s operational phase. A simplified life cycle model was used for quantifying the related emissions subject to the thermodynamic operation of the cycle for each refrigerant. The analysis was done using the Engineering Equation Solver. The results revealed R114 and R600a as the refrigerants with the highest emissions of greenhouse gases amongst all others when all refrigerants are operating under the same conditions, but with the potential to generate the highest power from the system. Within the estimated 20 years system life cycle, the system can emit as much as 6.5 tons of carbon dioxide equivalent, while generating 66 KW of turbine power with R113 as the working fluid. The results can assist in the optimal refrigerant choice with regards to environmental sustainability, operating cost, and performance efficiency in the adapted power-cooling system.