Introduction: Skin is one of the largest and prime sensory organs in the body.  Skin biopsy is a simple and inexpensive procedure which can help in consolidating clinical diagnosis and help further management. The present study was performed with the objective of describing spectrum of skin lesions in relation to its histopathological features, age, sex and site of involvement. Materials and Methods: The present study was a retrospective study carried out over a period of one year (January 2016-January 2017) in a tertiary care hospital. Histopathological details, along with age, gender, site of distribution and type of lesion were tabulated. Results: A total of 280 skin biopsies were analyzed. Most of the cases fell in the age range of 30-40 years. Upper extremity was the commonest site. Majority were non neoplastic conditions (68.92%), followed by inconclusive cases (27.5%) and neoplastic lesions (3.57%). In non neoplastic lesions maximum fell into the category of non?infectious erythematous papular and squamous disease (48.7%). In neoplastic lesions, squamous cell carcinoma was the most common (50%). Conclusion:  Dermatological lesions are by nature, heterogeneous with a varying age range, site distribution and histopathological features. The gold standard of diagnosis is histopathological examination which in conjunction with ancillary techniques and special stains, help in confirming the clinical diagnosis and improving patient management.