Introduction: Adolescence is a period of transition from childhood to adulthood, characterized by significant changes and challenges in physical, cognitive, and psychosocial development and known as a period of ‘storm and stress’. Neglecting these challenges can lead to negative identity formation and unpreparedness for future hurdles. This literature review explores the role of life skills enhancement programs in promoting the holistic well-being of adolescents. Materials and Methods: A narrative review was done to study and summarize prior research and find gaps and advancements in the area of study. PubMed, Google Scholar, CINAHL, and physical search in the hard copies of journals were done to choose materials. 101relevant `studies were identified highlighting the implications of childhood obesity, psychosocial changes in adolescence, factors affecting well-being and the role of Life Skills Education programs.  Findings: There are adequate studies to support the concern of childhood obesity and its implications. Psychosocial changes in the adolescent period, issues, and challenges are also being addressed adequately. The effectiveness of life skills programs in addressing these issues was supported by the literature. Limitations: Majority of studies were school-based with limited research on non-school-going adolescents. Given the increase in school dropouts during the pandemic, it is crucial to develop programs catering to the needs of this vulnerable population. Expanding the life skills programs