Problem. This study was conducted to find the antioxidant properties and its roles as photoprotector and anti-inflammatory agent in sunburn model mice. Approach. Biochemistry with spectrophotometer was conducted to trace the content of flavonoid, phenols, saponin, tannin, steroid (qualitative). The snail slime was divided into 4 concentration 20%, 50%, 70% and 100% that were applied onto the back of the mice 1hour prior UV radiation. This experimental study with test only control group design was conducted to study photoprotector and anti-inflammatory role a by using 75 Mus musculus BALB/c sunburn model mice were divided into 15 groups. The photoprotector effect was measured semi-quantitatively from the histopathologic changes 24 hours after radiation, meanwhile the anti-inflammatory effect was determined by using immunohistochemistry of anti-Interleukin-6 (IL-6) and leukocytes count of peripheral blood. Findings. The A. fulica snail slime extract was proven to contain flavonoid (+++), phenols (++), saponin (+++) and steroid (++). Snail slime application prior UV radiation showed significantly (p<0,000) prevent the histopathologic changes of the skin in sunburn effect from the lowest concentration 20%, it showed to prevent sunburn cell formation, crust formation, ulceration and dermal inflammation. The result of immunohistochemistry of anti-IL-6 also showed the snail slime also prevented the release of IL-6 in sunburn significantly (p<0,01) and decreased the leukocyte count of peripheral blood (p<0,000). Conclusion. The A.fulica snail slime contained antioxidant properties such as flavonoid, phenols, saponin and steroid, and potentially played role as photoprotector and anti-inflammatory agent in sunburn