Published Paper


Utility of Mixing Studies for Screening Haemophilia in a Resource Limited Hospital Setting

Dr. Ashim Manta, Dr. Gayatri Gogoi, Dr. Nitu Mani Khakhlari,
India
Page: 1117-1120
Published on: 2023 September

Abstract

Background: Mixing studies are initial screening tests done in cases of suspected bleeding disorders. In cases with abnormal coagulation test, they help differentiate if the prolongation in time is due to deficiency of Factor or due to presence of an inhibitor. The principle is that the normal plasma contributes a sufficient concentration of clotting factors to correct for a factor deficiency. Factor deficient plasma are commercially available but are very expensive. However the reagents for mixing studies can be prepared in the laboratory, thereby making it cost effective. Method: The study was conducted in the Department of Pathology, Assam Medical College & Hospital, Dibrugarh. The duration of our study was from June 2017 to July 2018. The clinical details were collected from the patients. The patients were tested for bleeding time, platelet count, Prothrombin time, Activated partial thromboplastin time and mixing studies. Results: Total number of cases in the study was 36, of which 31 were male patients and 5 female patients. Hemophilia A was found in 14 cases, haemophilia B in 2 cases, inhibitor was detected in 3 cases and 17 cases had normal values. Conclusion: Mixing studies are cost effective diagnostic screening tests for evaluation of abnormal coagulation tests.

 

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