Problem: Among other things, the continuous failure of chemistry students in both internal and external examinations has been attributed to the students' negative views toward the subject. Using the virtual laboratory strategy may improve students' attitudes toward chemistry. In light of the possibility for virtual experiments to offer a solution for learning at home in an emergency situation made necessary by security concerns, it is necessary to investigate this element. There is, in fact, continuous discussion regarding the relative merits of the face-to-face laboratory approach vs the virtual laboratory strategy for improving students learning results. The key question is whether or not using a virtual laboratory can improve students' attitudes toward chemistry. Answering this question constitute the problem of this study. Approach: A quasi-experimental design pre-test, post-test control group was adopted for the study. The population of the study consists of all the public senior secondary school three (SSS III) students offering chemistry in Kogi State. One hundred and seventy-six (176) students were sampled from four co-educational schools using multi-stage sampling technique. A validated instrument titled: Test of Practical Chemistry Attitude Scale (TPCAS) was used for data collection with a reliability coefficient of 0.81 using Pearson Product Moment Correlation. Two research questions and two hypotheses guided the study. The two research questions raised were answered using mean and standard deviation while the two null hypotheses were tested using ANCOVA at 0.05 level of significance. Findings: the results of findings showed that there was significant difference between the mean attitude rating scores of students taught practical chemistry using virtual laboratory strategy and those taught using face-to-face laboratory, in favour of virtual laboratory strategy. Additionally, the results showed that gender difference exists when virtual laboratory strategy are applied in favour of male students that had higher positive attitude toward chemistry practicals. Conclusion: implications of the findings of this study in relation to global security challenges were discussed and the study concluded that government at various levels should provide all the necessary facilities for virtual experiments in order to encourage students to carry out virtual laboratory experiments at home, which in long run will help to address the barriers posed by the global security challenges.