Introduction: Technological developments in automated cell separators have significantly increased the productivity and quality of apheresis platelet collection. Several studies on automated Plateletpheresis have been performed to examine platelet concentrate quality and its relationship to the donor's biological contribution (platelet count and/or total mass). Traditional blood giving, on the other hand, involves taking a unit of whole blood from a donor and sending it to a laboratory to be separated into its four components - red blood cells, white blood cells, platelets, and plasma. The components are stored and, based on the medical need, are administered to patients following surgery, an accident, sickness, or chemotherapy. While the donor is still connected to the separation apparatus, apheresis separates the blood into these components. Materials and Methods: The present study was carried out to evaluate the platelet collection from apheresis devices and compare the efficiency of platelet collection processing time, platelet yield, and ACD used. All Plateletpheresis procedures were performed following the departmental standard operating procedure using a closed system apheresis kit and ACD-A anticoagulant in the proportion of 1:12. The endpoint of each procedure was based on the target yield of 3x10¹¹ platelets per unit maintaining a blood flow rate for all collections at 50-80 mL/min. To measure the pre-and post-donation hematological values, whole blood samples were collected in EDTA vials just before and within 30 minutes after the procedure. Result & Observation: A total of 156 donors underwent apheresis, of which 147 (94.23%) were men and 09 (5.76%) were women. Majority of the donor 94.23% are male donor and very few 5.76% are female donor. The average procedure time required by SN was 86.41 minutes, while the average procedure time by DN was 70.79 minutes. According to mean values, the product yield in SN was 3.10 lac/L and in DN it was 3.11 lac/L. The difference in the end product count between the two was 8.82 lac/L in SN and 8.90 lac/L in DN. The amount of ACD used varied depending on the process, ranging from 220 ml to 460 ml on average in the procedure done on fresenius.com.tec. The procedure's duration was found to be significant with a p-value of 0.000, and the amount of ACD used was also found to be significant with a p-value of 0.001. Conclusion: The overall mean value of the different parameters in the study was analyzed, and the student t-test was used to determine the significance of the value. Of all the parameters, the time spent performing the procedure was found to be significant with a p-value of 0.000, and the amount of ACD used was also found to be significant with a p-value of 0.001. Product yield, total product count, and processing time for the DN procedure were all significantly better than for the SN method.