Issues: Cereal grains form the basis of livestock/ poultry feed and as such there is stiff competition between man, industries and animal for these grains as food; hence hike in prices of cereal grains which translate into high cost of finished animal products. The use of alternative feedstuff that is less competed for and with similar nutritional value will bridge this gap.  Methods: A study was conducted to investigate the effect of fermented Prosopis africanapod meal (FPAPM) on performance, cost effectiveness and serum biochemical indices of broiler chicks. A four week feeding trial was conducted using 150 day old Ambor acre strain of broiler chicks. Five experimental diets containing 0, 25, 50, 75 and 100% Prosopis africana pod fermented with rumen fluid were used to replace maize in a completely randomized design (CRD). Each treatment was replicated five times with thirty (30) birds per treatment. All standard and management practices were strictly observed. Data was collected on performance, cost effectiveness and serum biochemical indices. Findings: Results revealed that mean weekly feed intake, body weight, body weight gain and, feed conversion ratio were significantly (p<0.05) affected. Performance indices depreciate with increased levels of supplementation across treatment groups; the birds fed TI and T2 performed better.  Serum indices were not affected by the treatments.  Result revealed a progressive decrease in cost of feed (g) and cost of feed intake/bird (g) across treatments as the level of supplementation increased. The cost of feed/g weight gain was least with birds fed 25% FPAPM. Negative values were observed with feed cost savings per gram of meat, for 50%, 75% and 100% of FPAPM, thereby revealing that no savings accrued with supplementation of FPAPM at these levels. Conclusion: The study concluded that Prosopis africana pod fermented with rumen fluid could replace maize at 25% level in broiler chicks’ diets without compromising optimum productivity.