The use of plant based medicine has increased significantly in recent years due to the attraction of people towards to natural therapies. The herbal drugs traditionally used cure a variety of human aliments. The pharmaceutical companies are searching for new bioactive active compounds from angiospermic plants for a novel drug. The present study focused on the wound healing activity of ethanolic extract of Lepidagathis pungens Nees. (Acanthaceae). Male albino Wistar rats were used in the present study. Povidone iodine ointment was applied as standard drug. Sample at low dose (5%) and high dose (10%) were used to record the efficiency of plant extract. In excision wound model the potency of wound healing activity of the L. pungens ethanolic extract was found to be highly significant.