The heterocyclic aromatic chemical benzimidazole is created by joining a six-membered benzene ring with a five-membered imidazole ring. It has a variety of biological and therapeutic uses. Numerous investigations have demonstrated that different substituents placed all around the benzimidazole nucleus produce therapeutically valuable molecules that are pharmacologically active. This moiety is a preferred option of interest in the design and synthesis of novel medicinal compounds due to its variety of pharmacological characteristics. The benzimidazole core, which is present in many different biological agent classes, including anti-bacterial, anti-viral, anti-parasitic, anti-hypertensive, anti-cancer, anti-inflammatory, anticonvulsant, CNS stimulat and depressants has served as a crucial framework for the creation of countless newer therapeutic compounds. Understanding the synthesis and related functions of compounds produced from benzimidazoles in various disorders is crucial.Therefore, in this study, we make an effort to explore several benzimidazole nucleus derivatives with a variety of pharmacological actions.