Kerala possesses a rich legacy of manuscript traditions preserved in select institutional libraries across the state. This article examines selected manuscript libraries in Kerala with a focus on the nature of their collections, preservation practices, access facilities, and scholarly significance. The study highlights the diversity of manuscript materials—including palm leaf manuscripts and other non-book formats—and the efforts undertaken by these libraries to safeguard fragile cultural resources. By documenting current practices and challenges, the article underscores the role of manuscript libraries in preserving Kerala’s intellectual heritage and supporting research, education, and cultural continuity.