Tissue conditioners are used to improve ill-fitting dentures and also to treat abused mucosal tissues underlying ill-fitting acrylic dentures. The loss of surface integrity and surface roughness of tissue conditioners is regarded as the main problem resulting in inflammation of the oral mucosa in denture-bearing areas. Tissue conditioners are soft relining materials that provide a cushioning effect to the underlying tissues and thereby heal the abused tissues of inflammation and pain. Tissue conditioners are a mixture of polymer powder and plasticizer liquid. Conditioning the tissues also heals them by therapeutically providing antibacterial and antifungal properties.