This case report presents a 77-year-old female who developed painful oral swelling and ulceration after taking levofloxacin for a respiratory infection. The patient exhibited grade 1 stomatitis, characterized by ulcerative and erythematous lesions in the buccal and gingival mucosa, tongue, and lips. Upon discontinuation of levofloxacin and initiation of topical clotrimazole, mupirocin, and nystatin, the patient's condition improved within five days. This report highlights levofloxacin-induced stomatitis, an adverse drug reaction not previously documented. It underscores the need for careful monitoring of fluoroquinolone side effects and prompt discontinuation in suspected cases to prevent complications.