Loss of the continuity of the mandible destroys mandibular symmetry, function and presents a major challenge for prosthetic rehabilitation. These challenges include correction of deranged mandibular movements, disfigurement, functional difficulty seen during swallowing, speech and articulation, and deviation of the remaining mandibular structure to the surgical side. A corrective device known as guiding flange prosthesis (GFP) is used to limit these manifestations and guide the patient to reposition the mandible in the intercuspal position. As restoration of acceptable functional occlusion is one of the goals of maxillofacial prosthodontists, an interdisciplinary approach between oncologists/oral surgeons and prosthodontists is required while treating such patients. This technique report describes early prosthodontic management of two adults and one boy in his late childhood who had undergone hemi-mandibulectomy with acrylic GFP.