Background: General anaesthesia with laryngoscopy and intubation activates the sympathoadrenal system, which can lead to untoward complications in patients. As general anaesthesia with endotracheal intubation is widely performed daily, various methods have been adopted to reduce this pressor response to laryngoscopy and intubation. The popular practice is the use of intravenous lignocaine. A nebulized form of lignocaine may be a better alternative to obtund the intubation response. Methods: After obtaining ethical committee approval, 196 eligible, consenting adult patients belonging to ASA ? and ?? undergoing surgery under general anaesthesia in a tertiary teaching hospital were recruited and randomised into two groups— group A receiving 0.0375 ml/kg (1.5mg/kg) of nebulized 4% lignocaine and an equivalent volume of normal saline IV and group B receiving preservative-free 2% intravenous lignocaine 0.075 ml/kg (1.5mg/kg) and an equivalent volume of normal saline nebulization. Results: The parameters measured were SBP, DBP, MAP, HR, SpO2, duration of intubation and the number of attempts. The baseline vitals among both groups were comparable. At the time of intubation, the rise in all the haemodynamic parameters in group A was significantly lesser than that in group B with SBP of 129.48±7.9 and 134.08±11.55 (t= -3.256 p=0.001), DBP of 75.59±8.75  82.89±12.9 (t= -4.634 p= <0.001), MAP of 93.26±6.87 and 99.95±11.13 (t=5.066 p= <0.001), HR of 80.53±7.73 and 87.72±6.31 (t=7.136 p=<0.001) in group A and group B respectively. The mean duration of intubation was 15.96±3.04s and 16.15±3.55s (t= -0.41 p=0.681) respectively. There were no significant changes in SpO2 in either group. Conclusion: We conclude that the rise in haemodynamic response to laryngoscopy and intubation was significantly lower in the nebulized lignocaine group in comparison to the intravenous lignocaine group