Helicobacter pylori (H. pylori) infection is a significant cause of gastric disorders, including gastritis and ulcers. The increasing resistance to conventional antibiotics has highlighted the need for alternative treatments, particularly those derived from natural sources. This study reviews the antimicrobial and anti-ulcer properties of various plants traditionally used for gastrointestinal ailments. Plants such as Hydrastis canadensis, Mallotusphillipinesis, Myristicafragrans, Myrtuscommunis, Olea europaea, Perseaamericana, Phyllanthus niruri, and others have shown significant antibacterial activity against H. pylori, alongside notable anti-ulcer effects. These plants, rich in bioactive compounds like alkaloids, flavonoids, and essential oils, offer promising therapeutic potential for both ulcer treatment and H. pylori eradication. Among them, Sanguinaria canadensis and Punicagranatum have demonstrated strong antibacterial and anti-inflammatory activities, with the ability to mitigate gastric damage. The evidence suggests that these plant extracts could serve as viable alternatives or adjuncts to conventional therapies for treating H. pylori-induced ulcers and other gastric disorders. Further research, including clinical studies and pharmacological investigations, is necessary to evaluate their therapeutic safety and efficacy.