Background: Chronic Kidney Disease (CKD) is a global health challenge, affecting millions and leading to increased morbidity and mortality, particularly due to cardiovascular complications. Beyond its physical manifestations, CKD significantly impacts patients' mental health and quality of life (QoL). Material Methods: This cross-sectional study was conducted in the Department of General Medicine at SGT Hospital over 18 months. A total of 105 participants were divided into three groups: 35 healthy controls, 35 CKD patients not on hemodialysis (stages 3-5), and 35 CKD patients on maintenance hemodialysis. The DASS-21 questionnaire was used to assess mental health, and QoL was measured using the WHO-QoL BREF manual. Results: The study analyzed three groups: healthy controls, CKD patients not on hemodialysis, and CKD patients undergoing hemodialysis, with mean ages ranging from 45.85 to 47.94 years and a slight male predominance in all groups. CKD patients, particularly those on hemodialysis, showed higher rates of Diabetes Mellitus and Hypertension. Mental health assessments revealed that hemodialysis patients had significantly higher scores for Depression, Stress, and Anxiety. Additionally, these patients reported lower quality of life in all areas, especially in physical and psychological health, highlighting the severe impact of CKD on daily life and overall well-being. Conclusion: This study highlights the critical need for early identification and intervention strategies to address mental health and QoL in CKD patients. Comprehensive care that includes psychological support, lifestyle modifications, and regular monitoring of mental and physical health can potentially improve outcomes for patients across all stages of CKD.