Analysis of the percentage proximate composition and oil quality indices of selected Nigerian mango kernel were investigated. Four mango varieties (german, fazli, cherry and safeda) were sourced from Owerri, Imo State, Nigeria, processed, and their oil extracted using Soxhlet extractor, with n-hexane as solvent. AOAC standard procedures were adopted for the analyses, and the analyses were carried out in triplicates. The means were compared using The Origin Software at P>0.05. The proximate composition of kernel seeds showed that the percent ash, moisture, fat, fibre, protein and carbohydrate content varied from 1.501±0.036-4.786±0.302%, 2.495±0.559-3.98±0.537%, 6.947±1.339-10.484±0.685%, 2.096±0.419-3.861±0.652%, 1.344±0.345-1.736±0.33% and 78.24±0.622-81.644±0.487% respectively. Protein showed no significant difference in all the varieties investigated while there was significant difference in ash, moisture, fat, fibre, and carbohydrate. The physicochemical indices of the oil were as follow: smoke point (60±2.828-80±7.071 oC), refractive index (1.402±0.143-1.441±0.199), fire point (68±4.243-110±7.071 oC), flash point (55±7.071-82±2.823 oC), pH (6.42±0.044-7.51±0.014), viscosity (452.2±11.597-723.9±14.284Pas-1), density (0.856±0.079-0.938±0.0536 g/ml), specific gravity (0.36±0.057-0.442±0.059g/ml), free fatty acids (2.244±0.204-5.049±0.211), peroxide value (16.6±0.849-20.4±0.566g/ml)), acid value (4.488±0.266- 10.098±0.421mg/KOH/g), iodine value(29.269±0.769-40.978±1.478mg/g/g), saponification value (153.967±5.610-270.731±8.105mg/KOH). Similarly, refractive index showed no significant difference at P>0.05 in all the varieties investigated. Generally, the results indicated variations in proximate composition of mango kernels seeds, while the kernel seeds oil is a good source of fatty acids, with potentials as nutrient rich oil of economic value.