Background: The sciatic nerve, a critical component of the human nervous system, plays a pivotal role in the motor and sensory functions of the lower limb. Its anatomical relationship with the piriformis muscle is of particular interest due to its implications for both clinical practice and surgical interventions.[5] Variations in the emergence of the sciatic nerve in relation to the piriformis muscle can influence the presentation of sciatica, a common condition characterized by pain radiating along the nerve's distribution, and can complicate surgical procedures in the pelvic region[3]. Materials & Methods: In this study total number of 64 cadavers have been examined for different types of variations a total of three types of variations are found in this populationformalin-fixed cadavers, provided by the Department of Anatomy at our institution. Results: Out of 64 cadavers male cadavers are 32 and female cadavers 32. The total number of variations recorded are 15(23%) remaining 49 (77%) shows normal, where variations in males are 5(8%) and females are 10(16%) were recorded and the different types of variations and their prevalence in central India population were recorded and tabulated. Conclusion: This study underscores the significant anatomical variations in the emergence of the sciatic nerve in relation to the piriformis muscle in a Central Indian population, with notable differences between males and females. These findings highlight the importance of considering such variations in clinical practice