An efficient methodology employing for the preparation of 2-nitro -imidazole derivatives containing 1,3 -oxazinone  as a functional moiety by a one pot three component  reaction of substituted phenol, substituted aromatic aldehydes and urea / thiourea under microwave conditions has been presented.All the synthesized products were characterized  by elemental analysis and spectroscopy.Various imidazole-containing compounds have been tested for their medical usefulness in clinical trials for several disease conditions. The rapid expansion of imidazole-based medicinal chemistry suggests the promising and potential therapeutic values of imidazole-derived compounds for treating incurable diseases. Oxazinones are highly significant pharmacophoric scaffolds with a broad spectrum of biological activities, making them a vital class of compounds in medicinal chemistry. Various synthetic routes have been explored in the literature for producing aromatic oxazinones, showcasing the versatility of these compounds. Aromatic oxazinones were first synthesized in 1944 by Holly and Cope through Mannich reactions, utilizing phenols, formaldehyde, and amines. This pioneering work laid the foundation for further exploration of oxazinone derivatives in pharmaceutical applications. Over time, these heterocyclic compounds have garnered attention for their role as precursors in the synthesis of phosphinic ligands, which are widely employed in asymmetric catalysis. Given their diverse biological activities and utility in drug design, aromatic condensed oxazinone derivatives are regarded as ‘Privileged structures’ within the realm of pharmaceutical compounds. Their significance continues to grow, cementing their place in the development of novel therapeutic agents and catalytic processes.