Heavy metal pollutionis a dangerous environmental delinquent because of their tenacity, poisonousness,bio-accumulation in additionto biomagnifications properties. Heavymetal pollution can occur from different anthropogenic and normal sources in the ecosystem. Disintegration of rocks that bears metalsanderuption of volcanoes are natural bases of heavy metals while the farming and manufacturingactions,burning of fossil fuels and gasoline, mining and waste furnaces are anthropogenic bases of heavy metallic element.Addition of these heavy metals into waterecosystem,changes the physical and chemical naturesof water which is harmful for the flora and fauna of water.During the ingestion of metal accumulated food materials,the heavy metals pass into the fish body mainly through surface of the body,lamellae anddigestive tract.When the metal accumulated food materials and metal contaminated water is used by aquatic organisms such as fishes,the heavy metals pass in their bodyover the gills, musclesand alimentary canal.Cd-Cadmium,Cr-Chromium,Ni-Nicke,As-Arseni,Cu-Copper,Hg-Mercury,Zn-Zinc,Sn-Strontium, Mn-Manganese,Fe-Iron are the utmostusual heavy metal contaminants that createacutenoxiousness infishes.The basic molecular process of metal poisonousness is the growth of oxidative stress. The immune system is weakened By the oxidative stress, immune system is weakened and causes the damage of tissues and organs which leads to defect in the growth and ability of reproduction.The fish is a goodbasis ofOmega-3 fattyacids, vitamins and proteins.Hence, it encourages the human to eat fish as amain source of food.Therefore,the fish tissues within which the heavy metallic elements have been gathered are transmitted into the body of human being and lead to lethal effects to create severalillnesses.Hence,this is essential to discourse the toxic effects on the health of the fish to increase various diseases and the sources of heavy metals to imposethe rule and legislation about their safety in the environment of water in addition to protect life of human being.This study was conducted during the post monsoon period to determine the pollution water by heavy metals and bioaccumulation into fresh water fishes of Mystusseenghala,Cirrhinusreba,Labeocalbasu,Puntius ticto and Mystus vittatus from the RengaliDam in the river Brahmani of Angul district of the state Odisha.The tissues of gill and muscle of fishes were studied for the existence of heavy metals like Mn,Fe, Zn and Sn etc.usingX-Ray Fluorescence Spectroscopy studies.