Background: Gingivitis and periodontitis stand as the most common oral ailments, impact in gapproximately 50% of the adult human population. SA serves as a significant source of bacterial pathogens and plays a crucial role in the colonization of periodontal pathogens. It facilitates bacterial aggregation and contributes to the formation of pellicle and dental plaque. Aim: Toestimate and comparethesalivary Sialicacidlevelsinhealthy controls, gingivitis& chronic periodontitis patients. Material and Methods: Unstimulated whole saliva was collected from 60 participants Group I, (healthy controls, n=20), Group II (gingivitis, n=20), Group III (Individuals with periodontitis, n=20). Evaluation of periodontal health was done by calculating plaque index, measuring probing depth, and Clinical Attachment Loss (CAL). The saliva samples were collected, and centrifuged at8000 rpm for 12mins and biochemical analysis was done using the Acidic Ninhydrin method. Results: The mean salivary sialic acid levels in Group 3, Group 2, and Group 1 were 1.4785μg/ml, 1.115μg/ml, and 0.43μg/ml. These differences were found to best atistically significant (p<0.001). It is clear that as the severity of periodontal disease progresses from Group I to III, the average levels of SA in saliva also noticeably rise from Group I to Group III. Conclusion: Our study has shown significant results of increased salivary Sialic acid levels in periodontitis compared to healthy controls. Thereby estimation of salivary sialic acid levels is noninvasive, reliable, and cost-effective can be used as an adjunctto determine the current periodontal disease status, and monitor response to therapy, and assess the treatment outcomes.