Depression secondary to complex trauma presents unique diagnostic and therapeutic challenges. Complex trauma, resulting from repeated interpersonal adversities, disrupts emotional regulation and identity development, often leading to alexithymia and chronic mood disturbances. This case report describes a 37-year-old male with a severe depressive episode following prolonged psychosocial stress and unresolved trauma. The patient demonstrated significant improvement through combined pharmacotherapy and individualized cognitive-behavioural psychotherapy. The case underscores the importance of trauma-informed approaches in the management of depression resistant to conventional treatment.