Background: Chronic Suppurative Otitis Media (CSOM) is a persistent middle ear infection characterized by continuous ear discharge due to a perforated tympanic membrane. It is often associated with hearing loss and poses significant social, psychological, and physical challenges. Aim: This study aimed to evaluate the demographic characteristics and impact of CSOM on patients' quality of life (QoL) at a tertiary care hospital. Methodology: A prospective observational study was conducted over six months at the Department of ENT, Government General Hospital, Kurnool. A total of 110 patients diagnosed with CSOM were included. Participants' demographic data were collected, and QoL was assessed using the COMAT-15 scale. Statistical analysis included chi-square tests, paired t-tests, and descriptive measures (mean, median, mode). Results: Out of the 110 patients participated in the study, 52 were male and 58 were female, with ages ranging from 18 to 65 years. The majority of the patients were seen from the age group (18-28). patients were assessed using a standardized QOL questionnaire (COMAT- 15 SCALE), and the correlation between the severity of the disease and its influence on daily living was analyzed. Social interactions, physical activity, and emotional well-being among patients have improved. Discussion: The findings indicate that CSOM significantly affects various dimensions of patients' QoL. Using Standardized QoL tools like the COMAT-15 scale allows for better understanding and management of the psychosocial burden associated with the disease. This study focused to assess the clinical, psychological and treatment outcomes in patients with chronic suppurative Otitis Media (CSOM), focusing on demographic variables, symptomatology, quality of life before and after intervention and psychological burden. Conclusion: Chronic Suppurative Otitis Media has a profound impact on the quality of life of affected individuals, particularly in terms of social and psychological well-being. This study underscores the importance of a comprehensive management strategy that addresses the full spectrum of the disease, including physical, social and emotional health. Early diagnosis and intervention, along with access to adequate healthcare facilities, can significantly improve the outcomes for patients with CSOM.