The current study was conducted between the research year 2023-2024 and 2024-25 in research centre Janta College, Bakewar, Etawah, Department of Horticulture. The investigation was carried out in RBD (Randomized Block Design) with 3 replications, 26 treatments with 78 total number of combination. A field experiment was escort to assess the effect of foliar application of nutrients with plant growth regulators with 26 treatment combination T₁ = Urea, T₂ = K₂SO₄, T₃ = CaSO₄, T₄ = GA₃, T₅ = NAA, T₆= Urea + K₂SO₄, T₇= Urea + CaSO₄, T₈= Urea + GA₃, T₉= Urea + NAA, T₁₀= K₂SO₄+ CaSO₄, T₁₁= K₂SO₄ + GA₃, T₁₂= K₂SO₄ + NAA, T₁₃= CaSO₄ + GA₃, T₁₄= CaSO₄ + NAA, T₁₅= Urea + K₂SO₄ + CaSO₄, T₁₆= Urea + K₂SO₄ + GA₃, T₁₇= Urea + K₂SO₄ + NAA, T₁₈= Urea + CaSO₄ + GA₃, T₁₉= Urea + CaSO₄ + NAA, T₂₀= Urea + GA₃ + NAA, T₂₁= K₂SO₄ + CaSO₄ + GA₃, T₂₂= K₂SO₄ + CaSO₄ + NAA, T₂₃= CaSO₄ + GA₃ + NAA, T₂₄= GA₃ + NAA + K₂SO₄, T₂₅= Urea + K₂SO₄ + CaSO₄ + GA₃ + NAA, T₂₆= Control (RDF) on yield attributes and quality of guava (Psidium guajava L.) cv. L-49. Foliar application of Urea + K₂SO₄+ CaSO₄+ GA₃+ NAA increasing fruit yield characteristics like length of fruit, width of fruit, number of seeds and fruit yield in kg/tree and chemical parameters like T.S.S., sugar contains like reducing, non- reducing, total sugars and ascorbic acid of fruits. The foliar application of Urea + K₂SO₄ + CaSO₄+ GA₃ + NAA concentrations given more superior flowering, fruit set and fruit yield in guava and followed by Urea+ K₂SO₄ + NAA whereas, the control (RDF) was recorded the lesser value in all the treatment on fruit yield attributes and quality of winter season of guava (Psidium guajava L.) Cv. L-49.