Background: Sleep disturbances in infants are a common challenge, significantly impacting both infant well-being and caregiver mental health. The 5 S's technique—Swaddling, Shushing, Swinging, Sucking, and Side/Stomach positioning—offers a structured, non-pharmacological approach to improve sleep and reduce crying in infants. Objective: This systematic review evaluates the effectiveness of the 5 S's technique in promoting sleep, calming infants, and reducing caregiver stress, based on evidence from 55 studies. Methods: A comprehensive literature search identified randomized controlled trials, cohort studies, cross-sectional analyses, and systematic reviews published between 2015 and 2024. Study populations included healthy, colicky, preterm, and NICU infants. Data on sleep outcomes, crying reduction, and caregiver stress were synthesized. Results: The findings demonstrate that the 5 S's technique is consistently effective in improving infant sleep onset, duration, and continuity. Swaddling reduced the Moro reflex and facilitated sleep, while shushing and swinging showed significant calming effects on over stimulated infants. Sucking enhanced self-soothing behaviors and stabilized sleep patterns. The combined use of the 5 S's was the most effective approach, especially for managing colic and fostering caregiver-infant bonding. Strengths: The reviewed studies featured diverse populations, robust methodologies, and practical applications in both clinical (e.g., NICU) and home settings. Limitations: Common limitations included small sample sizes, cultural variability in implementation, and limited follow-up periods to assess long-term outcomes. Conclusion: The 5 S's technique is a safe, accessible, and highly effective method for managing infant sleep disturbances and reducing caregiver stress. Training caregivers in proper implementation and conducting longitudinal studies to explore lasting benefits are recommended for future research