Background: Overseas Filipino Worker (OFW) nurses face unique migration experiences and integration challenges in foreign healthcare systems. This study explores the experiences of OFW nurses working at King Khalid Hospital in Najran, Saudi Arabia, focusing on their migration, workforce integration, and adaptation strategies. Objectives: The study aims to investigate the migration experiences, challenges, coping strategies, and the impact of integration into the healthcare system on the professional and personal lives of OFW nurses. Methods: This qualitative study uses phenomenological methodology. Twelve OFW nurses, with employment durations ranging from six months to five years at King Khalid Hospital, were purposively selected. Data were collected through in-depth interviews and analyzed using thematic analysis. Results: Four themes emerged from the data: (1) Migration Experience: Financial incentives, professional development opportunities, and expedited processing were key motivators, despite challenges like cultural differences and legal issues. (2) Workplace Integration: Structured orientation and professional resources facilitated adaptation, with many nurses reporting improved workplace culture. (3) Coping Strategies: Social support, engagement in local activities, self-care practices, and technology use were vital for cultural adjustment. (4) Long-term Impact: Nurses experienced professional growth, enhanced cultural competence, and improved confidence, despite occasional language barriers. Conclusion: Tailored support programs are essential for OFW nurses’ successful migration and integration. This study highlights the importance of structured support to facilitate their adaptation, improve cultural competence, and enhance their professional growth.