Topic: A study to assess the knowledge regarding Standard Precautions among student Nurses. Background: Nurses are the principal group of health care personnel in all health care settings. Nurse’s lack of knowledge may be a barrier in prevention of infections. Aim: The objectives of the study were to assess the student nurses knowledge regarding Standard Precautions and to assess the relationship between student nurses knowledge regarding Standard precautions and selected variables. Method: This cross-sectional study was conducted between student nurses at first, second and third years at Bhaarath college of Nursing, samples were selected using convenient sampling method. A validated self-prepared questionnaire was used to assess the knowledge. Results: 65 %(n=98) had very good knowledge, 4% of samples (n=4) had good knowledge, 3% of samples (n=3) had average knowledge and 28% of samples (n=42) of samples had below average knowledge. Conclusion: The findings obtained in this study by analyzing data from survey shows two-third of the participants have adequate knowledge on standard precaution. Hence regular courses should be held especially for the nursing students who are posted in critical care units as well as continuous monitoring of complianceby the nursing educators and Nursing supervisor. A holistic approach should be taken by the Teaching faculty,nurse educator, nurse manager, and nurses to overcome this problem.