This paper examined the Impact of Religion on Populace Participation in Politics for National Development. Religion, the opium of the masses, has become a strong determining factor for people’s participation in politics. The influence of religion on politics is visible in the participation of the populace in political matters or issues. This means religion can enhance or affect national development. The research adopted a descriptive design while data was reported qualitatively. Findings revealed that religion had contributed positively and negatively to politics and that some adherence to religious and moral values enhanced peace and national development. At the same time, some disturbed progressive peace and national development. The work recommends that political officeholders adhere to the positive tenets of their faiths, which promote the welfare of the human race.